Host-Pathogen Interactions, Virology
Disease Research Interests
Immune evasion strategies of viruses; molecular disinfection of viruses; molecular tracking viruses in the environment
Viruses are one of the most abundant microorganisms on the planet, infecting every form of life from humans to bacteria. Mammalian viruses, many of which are zoonotic (i.e., transmitted to humans from other animals), are directly responsible for some of the worst diseases known to man (e.g., Ebola virus, HIV), and for common causes of morbidity and mortality around the world (e.g., norovirus, influenza virus).
Understanding, detecting and controlling viruses continue to be grand challenges in science because so little is known about the fundamental properties of viruses and their interactions with the environment, and because they vary greatly with respect to their genomes and replication cycles.
I am interested in asking fundamental questions about virology:
- What are the molecular properties of viruses that make them resistant or susceptible to disinfection in natural settings versus hospitals or water treatment plants?
- How do viruses evade the immune system to cause disease?
- How does the physical environment affect virus evolution and spread?
B.A. (Microbiology), Miami University, 1990
Ph.D. (Immunology and Molecular Pathogenesis), Emory University, 1996
Postdoctoral (Virology), Laboratory of Viral Diseases, National Institutes of Health, 1997-2001
Additional Campus Affiliations
Oh, C., Kim, K., Araud, E., Wang, L., Shisler, J. L., & Nguyen, T. H. (2022). A novel approach to concentrate human and animal viruses from wastewater using receptors-conjugated magnetic beads. Water Research, 212, . https://doi.org/10.1016/j.watres.2022.118112
Oh, C., Zhou, A., O'Brien, K., Jamal, Y., Wennerdahl, H., Schmidt, A. R., Shisler, J. L., Jutla, A., Schmidt IV, A. R., Keefer, L., Brown, W. M., & Nguyen, T. H. (2022). Application of neighborhood-scale wastewater-based epidemiology in low COVID-19 incidence situations. Science of the Total Environment, 852, . https://doi.org/10.1016/j.scitotenv.2022.158448
Oh, C., Chowdhury, R., Samineni, L., Shisler, J. L., Kumar, M., & Nguyen, T. H. (2022). Inactivation Mechanism and Efficacy of Grape Seed Extract for Human Norovirus Surrogate. Applied and environmental microbiology, 88(9), [e02247-21]. https://doi.org/10.1128/aem.02247-21
Fuzawa, M., Duan, J., Shisler, J. L., & Nguyen, T. H. (2021). Peracetic Acid Sanitation on Arugula Microgreens Contaminated with Surface-Attached and Internalized Tulane Virus and Rotavirus. Food and Environmental Virology, 13(3), 401-411. https://doi.org/10.1007/s12560-021-09473-1
Mao, Y., Zeineldin, M., Usmani, M., Uprety, S., Shisler, J. L., Jutla, A., Unnikrishnan, A., & Nguyen, T. H. (2021). Distribution and Antibiotic Resistance Profiles of Salmonella enterica in Rural Areas of North Carolina After Hurricane Florence in 2018. GeoHealth, 5(2), [e2020GH000294]. https://doi.org/10.1029/2020GH000294